Survival in high-risk prostate cancer patients is predicted by mir-221, which regulates proliferation, apoptosis and invasion of prostate cancer cells by inhibiting IRF2 and SOCS3

Burkhard Kneitz, Markus Krebs, Charis Kalogirou, Maria Schubert, Steven Joniau, Hein van Poppel, Evelyne Lerut, Susanne Kneitz, Claus Jürgen Scholz, Philipp Ströbel, Manfred Gessler Hubertus Riedmiller, 1,2 Martin Spahn 1 Department of Urology and Paediatric Urology, University Hospital Wuerzburg, Würzburg, Germany 2 Department of Urology, University Hospital Bern, Inselspital, Bern, Switzerland Department of Urology, University Hospital Leuven, Leuven, Belgium Department of Pathology, University Hospital Leuven, Leuven, Belgium Physiological Chemistry I, Biocenter, University of Wuerzburg, Wuerzburg, Germany IZKF Laboratory for Microarray Applications, University Hospital of Wuerzburg, Wuerzburg, Germany Department of Pathology, University Hospital Goettingen, Goettingen, Germany Developmental Biochemistry, Biocenter, University of Wuerzburg, Wuerzburg, Germany.